ABSTRACT
Objective:To explore the clinical effect of prostatil combined with diosmin on the elderly patients with chronic prostatitis (CP) and the macrophage inflammatory protein-2 (MIP-2) and macrophage inflammatory protein-lα (MIP-lα) in prostate fluid and serum.Methods:126 cases of elderly patients with CP in our hospital fiom January 2015 to September 2016 were selected and randomly divided into two groups.Prostatil combined with diosmin were provided to the patients in observation groups (63 cases) while the control group (63 cases) was treated by prostatil alone.The clinical effect,MIP-2,MIP-1α levels in the prostate fluid and serum before and after therapy as well as the incidence of adverse reactions were observed and compared between two groups.Results:At 12 weeks after treatment,the total effective rate of observation group was 93.7％,which was obviously higher than that of the control group (81.0％,P＜0.05).The MIP-2 and MIP-1α levels in prostate fluid and serum of both groups at 12 weeks after therapy were significantly lower than those before therapy (P＜0.01),which were significantly lower in the observation group than those of the control group at the same time (P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:Prostatil combined with diosmin could more safely and effectively improve the clinical efficacy in the treatment of elderly patients with CP/CPPS,which might be related to reduce the levels ofMIP-2,MIP-lα in serum and prostatic fluid.
ABSTRACT
Objective To evaluate the safety and efficacy of using blunt-tip needle to suture the dorsal venous complex (DVC) in laparoscopic radical prostatectomy. Methods The clinical data and the operation videos of patients, who received laparoscopic and robot-assisted radical prostatectomies by a single surgeon in our hospital from Jan. 2012 to Jul. 2014, were retrospectively reviewed. The needles used to suture DVC, exposure of suture points, bleeding of DVC, and cases of mistakenly sutured catheter and positive margins at the epic were analyzed. Continence of patients was followed and analyzed 3 months after surgery. Results A total of 104 cases were enrolled in this study. DVC was sutured with traditional needles in 56 cases, and in 52 of them the junction between prostate epic and membranous urethra (so called golden eye) could be exposed. DVC was sutured with blunt-tip needles in 48 cases, and the "golden eye" could be found in 44 of them. Suturing with blunt-tip needles, compared with traditional needles, resulted in significantly less bleeding and significantly better continence recovery (P<0.05). Conclusion Dorsal venous complex can be completely sutured by using blunt-tip needle once the "golden eye" is correctly indentified, which can decease the intraoperative bleeding and maintain a clear surgical field, improving the postoperative continence recovery.